ISR3D is a specific example of a more general model for neointima (new tissue) formation in the cardiovascular system, which plays an especially large role in recovery after medical intravascular intervention, e.g. in healing and scar formation. Such a general model is here used to develop NeoIntima3D, a solution that predicts the risk of late thrombosis in vascular stenting.
Late thrombosis is a particularly dangerous condition. The thrombus that forms on a thrombogenic surface, such as an arterial ulcer or exposed metal struts of a stent, may break off and completely cut off the blood flow in the artery. The exact reasons and mechanisms of late thrombosis are still ill-understood. It is a rather infrequent event, e.g. late stent thrombosis happens in less than 1% cases, but if it occurs, it leads to myocardial infarction and death in up to 80% of cases.
What is currently missing are models that are capable to predict such long-term effects as late thrombosis. Validation will then be along two lines, one to predict if and where a thrombosis may form, and one to predict when a thrombus could form. The first line will depend on microfluidics data, the second on clinical data.