The Universal Immune System Simulator – Tuberculosis (UISS-TB) is a simulator of the immune system dynamics, particularly tailored to predict the response of the human immune system to the exposure to Mycobacterium tuberculosis. 

It can be used as an in silico lab to predict the outcome of new vaccination strategies for active tuberculosis and it has already been validated with available data coming from clinical trials of two vaccines (RUTI and ID93+GLA-SE). 

The consortium plans to complete its validation using anonymized data coming from patients enrolled in the STriTuVaD EC funded project, with a regulatory submission of qualification advice.