The Universal Immune System Simulator – COVID19  (UISS-COVID19) predicts the dynamics of SARS-CoV-2 immune system competition within the host. COVID19 is a severe respiratory infection that affects humans and its outburst recently became a pandemic emergency. 

To promptly and rapidly respond to these dramatic pandemic events, the application of in silico trials can be used for designing and testing medicines against SARS-CoV-2 and speedup the vaccine discovery pipeline, predicting any therapeutic failure and minimizing undesired effects. 

UISS-COVID19 consists in an in silico platform that showed to be in very good agreement with the latest literature outcome in predicting SARS-CoV-2 dynamics and related immune system host response, including cytokines involvement.

Moreover, it has been used to predict the outcome of several approaches to design an effective vaccines and therapies. UISS-COVID19 is ready to be used as an in silico trial platform to predict the outcome of vaccination strategy against SARS-CoV-2.

The In Silico World planned work is to validate this code with a medium-size cohort of clinical cases collected from specific literature clinical studies.