Through its linked third party Istituto Ortopedico Rizzoli (IOR), UNIBO has access to over 4000 CT scans of the thigh region, originally collected to provide CT-based surgical planning of a total hip replacement procedure, but under an informed consent that included also secondary use for research.
Of these, around 5% are of patients are now deceased, and thus can be publicly shared when irreversibly anonymized, only after the permission of IOR local ethical committee.
To generate a heterogeneous finite element model of the patient’s femur the BoneStrength simulation workflow requires the CT images to be:
• densitometrically calibrated
• meshed with parabolic tetrahedra
• re-projected back onto the calibrated CT data
Thus, in addition to the primary medical imaging data, UNIBO will share collections of derivative data such as polygonal surfaces from segmentations, finite element meshes, mineral density 3D maps, etc.
UNIBO will also plan to explore the generation of synthetic data collections, specifically toward the generation of virtual cohorts for phase III In Silico Trials (with over 1000 virtual patients).